Changes in metabolic toxicity after switching from stavudine/didanosine to tenofovir/lamivudine--a Staccato trial substudy
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Changes in metabolic toxicity after switching from stavudine/didanosine to tenofovir/lamivudine--a Staccato trial substudy.
OBJECTIVES Stavudine is widely used in Thailand and is associated with mitochondrial toxicity. Here, we evaluated the effect of switching from stavudine/didanosine to tenofovir/lamivudine on measures of metabolic and mitochondrial toxicity in Thai patients. METHODS Thirty-five Thai patients with full HIV RNA suppression were switched from stavudine/didanosine to tenofovir/lamivudine while rec...
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متن کاملMetabolic and anthropometric changes one year after switching from didanosine/stavudine to tenofovir in HIV-infected patients.
BACKGROUND Nucleoside analogues such as Didanosine and Stavudine are known to cause metabolic and body habitus changes during antiretroviral therapy. The most frequently observed are lactic acidosis, hypercholesterinaemia, hypertriglyceridaemia and lipodystrophy. METHODS Over one year we monitored a cohort of 43 patients who switched from either Stavudine, Didanosine or the combination of bot...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2008
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkn097